Bird Flu Virus H5N1: A New Pandemic Threat for the World

The role of the global organization is to inform the world about health issues. The World Health Organisation plays an important role in awakening people about diseases and their consequences. It was April 1, 2024, in the United States of America. The laboratory confirmed human infection with influenza A (H5N1). The patient began exhibiting symptoms on March 27, marking the second reported case in the United States of America. Despite the lack of associated cases, this virus poses a health risk to the general population. Exposure could potentially increase the risk of infection in the future. So there must be precautions adopted by the population, and the World Health Organisation plays its role in making people aware of the virus that may be harmful as compared to COVID-19.

Figure 1: Virus and its effect H5N1
Figure 1: Virus and its effect H5N1

American Strategies about Virus A (H5N1)

The United States CDC continues playing its role and awaking people about this virus. The United States of America is collaborating with various departments to develop a single, comprehensive approach. The report confirms the presence of a virus infection in 42 dairy cattle herds in the United States. As previously mentioned, we reported one case on April 1, 2024, and currently, we are monitoring 260 individuals exhibiting symptoms of this virus (United States).

Vietnam, Southeast Asia Country, Case Reported

A 21-year-old man in Vietnam’s Khanh Hoa province has contracted the influenza H5N1 virus. The medical report shows this man was observed on March 11, 2024, with a fever and cough, and he was admitted on March 15, 2024, but there is a swearing of abdominal pain and diarrhoea. After the cough and fever, the patient was transferred to another hospital, and he was diagnosed with influenza and H5N1. This man died on March 20, 2024.

Figure 2: Vietnam's Khanh Hoa province
Figure 2: Vietnam’s Khanh Hoa province

Animals Influenza and Avian Influenza

There is a common case where animal influenza circulates in animals, not humans, but in rare cases due to the environment, this can affect humans. The direct connection between humans and animals may affect human health, and viruses can be transferred to humans through food. The other virus, commonly referred to as avian influenza, falls under the influenza A category. A specific host adopts a virus strain that causes animal flu. Avian influenza virus infections in humans can cause a range of diseases, from mild upper respiratory tract infections to more severe ones, and can be fatal. There have also been reports of conjunctivitis, gastrointestinal symptoms, encephalitis, and encephalopathy. Several asymptomatic individuals who had exposure to infected birds in the days prior to sample collection have also tested positive for the H5N1 virus.

Figure 3: Human interaction with animals
Figure 3: Human interaction with animals

Types of the Influenza Viruses

There are four types of influenza viruses: A,B,C, and D. There are two seasonal flus, Influenza A and B. This is almost every winter in the world. The influenza A virus, also known as the flu pandemic, is one of the only viruses that can cause a global epidemic of flu diseases. A pandemic can occur when a new and different influenza A virus emerges that infects people, has the ability to spread efficiently among people, and against which individuals have little or no immunity. Influenza C and D. The C virus causes mild illness, and the D virus primarily affects cattle, with spillover to other animals.

Figure 4: Types of Viruses
Figure 4: Types of Viruses

Virus H5N1 Is the Subtype of Influenza A Virus

The H5N1 virus is a subtype of the influenza A virus. Influenza primarily causes this in birds. The H5N1 virus can also affect mammals and humans, and in this case, the consequences may be dangerous and fatal. The infected birds shed this virus in their mucous, saliva, and faces. Cow milk also contains this virus. Due to the consequences, this billon of birds and animals was slaughtered to protect humans.  In the case of humans. Influenza A virus normally has symptoms that include fever, cough, sore throat, muscle aches, conjunctivitis, and, in severe cases, breathing problems and pneumonia that may be fatal. No one knows the other symptoms of the humanized H5N1 flu. According to WHO data, the mortality rate is high; 60 percent of the victim cases have died.

Figure 5: infected birds shed this virus in their mucous, saliva, and faces
Figure 5: infected birds shed this virus in their mucous, saliva, and faces

History of Influenza A Virus

If you have a history of influenza A virus, If you take it out and look, you will know the past. The pandemic has persisted throughout the century, culminating in 2024. Like many global epidemics, COVID has infected influenza A a total of 12 times. Among them, can you believe that there have been five cases of influenza A alone? Different strains of the virus have spread, and a new one has emerged once again. Powerful Strain H5A1. What’s even more dangerous is that, at the moment, this H5A1 is absolutely showing the same infection pattern as all the big purists have shown so far, especially COVID.

Figure 6: Virus Influenza A Virus
Figure 6: Virus Influenza A Virus

Virus in 1911

Years ago, in 1911, a Spanish flu outbreak occurred. The epidemic had spread, along with a strain of influenza A virus. This disease had spread in just two to three years. Between 1900 and 2024, the disease claimed the lives of approximately 5 to 10 crore people. Despite all the major epidemics, the total death toll exceeded everyone’s combined count. Having said that, the virus wasn’t particularly potent. At that time, starting around 1915, the Spanish had a less potent variant of the flu virus, which was shared by birds, farm pigs, and humans. People’s lack of awareness at the time prevented the virus from spreading. People didn’t take it seriously for a long time, but in 1918, the virus underwent a mutation that caused a sudden surge.

Figure 7: Historical imagination about virus
Figure 7: Historical imagination about virus

The Viruses Upto 2019

The cases started increasing, and after this, they started killing crores of people. The future continues to follow the same pattern, just as it did in 1957. In 2017, the Asian flu suddenly emerged and claimed the lives of nearly 20 lakh people; studies indicate that it was also the first sustained pandemic. There were cases, and then suddenly they started peaking. The Hong Kong flu came in 1968, first in small random cases and then in sudden ones. Once again, the flu claimed the lives of 20 lakh people, a pattern that the Russian flu subsequently replicated. Even during the COVID-19 pandemic, swine flu remained a surprise for two to three years.

Figure 8: Virus
Figure 8: Virus

The Virus’s Incubation Phase and Tipping Point

This is commonly referred to as the incubation phase when viruses grow. People often claim that humans resemble birds in nature. Our individual lives are in the bodies of animals. Adapting to biology means adapting and evolving. As soon as our body’s immune system learns to bypass the system, it will return. Its tipping point, i.e., that stage after which the cases of infection shot up suddenly, is that you will start getting upset and need someone to take care of you. Since then, he changed his name in November 2019. He appeared before the world from November to March. He was incubated by many people, and then suddenly his tipping point came in March, after which he went out of control. The pandemic, known as COVID-19, has affected countries worldwide.

Figure 9: Tipping point of virus
Figure 9: Tipping point of virus

Variants: A Genetic Material Game for Humans

Spread as a small, non-lethal virus there were small wild birds, but these affected the animals, affecting different species. It has two important receptors: A5 and na1, which bind it to different hosts. There have been significant changes in these receptors recently. They have come, and now they are even more deadly. Basically, where was he near his tipping point? He had literally reached H5A1, with 80 major mutations already present in the receptors’ genes, leading to the emergence of 80 genetic sub-lines of this virus. That means variants have been born, and these 80 variations affect 138 species today, giving rise to even more variations. Are If we don’t halt them promptly, the human-affecting variants will continue to spread. It is available in other variants. Sharing genetic material with humans led to the creation of a variant.

Influenza A (H5N1) is more deadly as compared to COVID.

The virus was airborne, i.e., when affected people sneeze or cough As a result, the virus hovered in the air, influencing numerous individuals while simultaneously causing a known or unknown illness. Recently, I conducted an experiment to determine the distance the particles travel when a person sneezes. It turns out we travel only for 22 seconds. They can reach up to 25 feet in just 22 seconds, which is more than the length of a minibus. There’s no way that a city has AIDS. If we find five cases, they will spread immediately throughout the city. The virus will spread, but since there isn’t a single case of COVID, the entire city will soon become infected. So imagine a virus in this situation. Influenza A (H5N1) is 50 times more deadly than COVID-19. Can you imagine how it spreads through various mediums? What will be the level of destruction?

Figure 11: World May face Condition
Figure 11: World May face Condition

Laboratory Tests

Laboratory tests are required to diagnose a human infection with influenza. WHO periodically updates technical guidance protocols for the detection of zoonotic influenza using molecular methods, e.g., RT-PCR. Evidence suggests that some antiviral drugs, notably neuraminidase inhibitors (oseltamivir, zanamivir), can reduce the duration of viral replication and improve the prospects of survival in some cases.

Figure 12: Laboratory Tests
Figure 12: Laboratory Tests

Awareness and Our Responsibility

Now that it’s over, the real question is: how can we stop this? As we’ve observed, H5N1 remains on the brink. It has not reached the point it is about to. That means it’s not too late; in the future, we are still preparing ourselves for what the pandemic can do, and to do that, first of all, we have to make ourselves aware. This awareness must have reached people at the time. Before the virus spreads, spread awareness. The second and most important thing is that we must only take care of real life, and that is our own responsibility.

Figure 13: Awareness and Responsibility about H5N1
Figure 13: Awareness and Responsibility about H5N1

This article discusses the H5N1 virus, which has the potential to be a global threat with potentially devastating consequences. This virus is in its tipping stage and moving to the incubation stage; we must prepare ourselves; otherwise, COVID-19 has not impacted as much, but the scientists have given the H5N1 virus a future picture that may be more dangerous. It is our responsibility to take care of ourselves and be aware of the virus. I am grateful to all my readers who have given me such love, care, and appreciation for continuing my research efforts. Thanks to all

Regards

Dr. Abid Hussain Nawaz

Post Doc, PhD, MPhil

 

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6 Comments

    1. At the end of this article, I have been mentioned,, sir, so please have a look again. Now, I’m emphasizing once more the importance of combating the virus and raising societal awareness about it.

  1. Eman Fatima says:

    Thank you for shedding light on the critical issue of the H5N1 bird flu virus and its potential threat to global health. Your in-depth analysis and clear explanation of the situation have helped raise awareness and understanding of this important topic. Your dedication to informing the public about the risks and necessary precautions is truly commendable. Keep up the excellent work!”

  2. As the virus is in tipping point and not in incubation point, we must take prevention steps before the virus gets viral general awareness about the virus is crucial to save the lives of thousands

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